Enhancement of solubility of Domperidone by using combination of solid dispersion and liquisolid techniques with natural and synthetic polymers
Solid dispersion.Liquisolid,Domperidone,Manihot,Liquid load factor,Slubility enhancement ratio and Bioavialability
Domperidone is a dopamine antagonist widely used as an antiemetic and gastroprokinetic agent; however, its therapeutic effectiveness is limited due to its poor aqueous solubility and low oral bioavailability. The present study aimed to enhance the solubility and dissolution rate of domperidone by employing a combined solid dispersion and liquisolid technique. Solid dispersions of domperidone were prepared using suitable natural and synthetic hydrophilic carriers(Manihot esculenta starch,Aloe vera gel powder and methyl cellulose) through a solvent evaporation method to improve drug wettability and dispersion. The optimized solid dispersion(drug:carrier ratio 1:3 was further incorporated into a liquisolid system using non-volatile solvent(Tween80), carrier materials(Manihot starch,Aloe vera gel powder and Micro crystalline cellulose), and coating material(Talc) to enhance the flow properties and compressibility.
Registration ID: IJVRA_701743 Published ID: IJVRA2603369
"Enhancement of solubility of Domperidone by using combination of solid dispersion and liquisolid techniques with natural and synthetic polymers", IJVRA - International Journal of Versatile Research and Analysis (www.IJVRA.org), ISSN:2984-8903, Vol.4, Issue 3, page no.811-824, March-2026, Available :https://ijpub.org/ijvra/papers/IJVRA2603369.pdf
Paper Reg. ID: IJVRA_701743
Published Paper Id: IJVRA2603369
Research Area: Other area not in list
Country: -, -, India
ISSN: 2984-8903 | IMPACT FACTOR: 9.12 Calculated By Google Scholar | ESTD YEAR: 2023
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Publisher: IJVRA (IJ Publication) Janvi Wave
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