Evaluation of Actinomycetes as a Potential Source of Novel Antimicrobial and Anticancer Compounds
Actinomycetes, Anticancer compounds, Antimicrobial activity, Drug discovery, Genome mining, Secondary metabolites.
Actinomycetes belong to a group of highly diverse Gram, positive bacteria characterized by their filamentous structure. They are most famous for their remarkable ability to synthesize bioactive secondary metabolites. These bacteria have been a major source of clinically important antibiotics and anticancer drugs throughout history. Due to the global rise in antimicrobial resistance and the limited effectiveness of current cancer therapies, researchers have increasingly focused on actinomycetes as a rich source of novel bioactive compounds. This review highlights the potential of actinomycetes to produce new antimicrobial and anticancer agents, with emphasis on their ecological diversity, biosynthetic potential, and metabolite diversity. Actinomycetes gathered from various and little, explored environments like soil, sea, and plant, associated niches have been found to possess strong antimicrobial properties against pathogenic bacteria and fungi apart from showing cytotoxic effects against different cancer cell lines. The latest developments in genome mining, metabolic engineering, and high, throughput screening methods have unraveled the existence of many silent biosynthetic gene clusters, which is indicative of the immense chemical space that remains unexplored. The discovery of unknown compounds is still possible to a certain extent, however, major hurdles such as the isolation of already known compounds and difficulties in large, scale production remain. New cultivation strategies and omics, based methodologies are bringing about a drug, discovery revival of actinomycetes by addressing these issues one at a time. The actinomycetes are still a treasure trove of yet to be discovered compounds and will continue to be so for the foreseeable future with next, generation antimicrobials and anticancer drugs as the final products.
Registration ID: IJVRA_701905 Published ID: IJVRA2603450
"Evaluation of Actinomycetes as a Potential Source of Novel Antimicrobial and Anticancer Compounds", IJVRA - International Journal of Versatile Research and Analysis (www.IJVRA.org), ISSN:2984-8903, Vol.4, Issue 3, page no.442-449, March-2026, Available :https://ijpub.org/ijvra/papers/IJVRA2603450.pdf
Paper Reg. ID: IJVRA_701905
Published Paper Id: IJVRA2603450
Research Area: Other area not in list
Country: Coimbatore , Tamilnadu , India
ISSN: 2984-8903 | IMPACT FACTOR: 9.12 Calculated By Google Scholar | ESTD YEAR: 2023
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